Post-acute sequelae of SARS-CoV-2 infection in children appears to be lower than in adults


A brand new examine performed by the Nationwide Institutes of Well being (NIH) RECOVER Pediatric Digital Well being Information (EHR) Cohort and authored by Suchitra Rao, MD, infectious illness specialist at Youngsters’s Hospital Colorado, discovered that the chance of post-acute sequelae of SARS-CoV-2 an infection (PASC), or lengthy COVID, in youngsters seems to be decrease than what has been reported in adults. Nevertheless, extra youngsters have lengthy COVID than these children who’re hospitalized with acute COVID-19. The examine is featured in JAMA Pediatrics.

We concluded that most of the signs youngsters expertise post-COVID-19 are comparable to what’s seen in adults, however there are some options extra distinctive to youngsters, similar to myocarditis, irregular liver enzymes, hair loss, pores and skin rashes and diarrhea. There was a important want to know the affect of COVID-19 in youngsters each within the brief in addition to long-term. That is one in every of greatest research we all know of to discover what the post-acute sequelae appear like in children. Research utilizing digital well being report information are a good way to discover analysis questions that require additional affirmation in long term potential research.”

Suchitra Rao, MD, infectious illness specialist at Youngsters’s Hospital Colorado

Whereas the presentation has some overlap in contrast with adults, distinct options exist in youngsters. The chance for PASC seems to be increased in youngsters youthful than 5 years of age, these with medical complexity and people admitted to the intensive care unit with their preliminary COVID-19 an infection.

The exploratory examine, “Syndromic, Systemic and Medicine Options of Publish-acute Sequelae of SARS-CoV-2 An infection in Youngsters and Adolescents: EHR-based Cohort Examine from the RECOVER Program,” used digital well being report information from PEDSnet member establishments of 659,286 youngsters examined for SARS-CoV-2 and in contrast 59,893 youngsters who examined optimistic with those that examined adverse.

The NIH RECOVER Pediatric EHR Cohort investigators performed a multistate evaluation utilizing EHR information of kids and other people youthful than 21 years of age who underwent testing for SARS-CoV-2 at one in every of eight pediatric well being programs within the nation between March 1, 2020, and Oct. 31, 2021. Clinicians recognized circumstances, signs and drugs related to PASC within the one to 6 months following testing. Out of 660,000 youngsters who underwent testing, 9% had been optimistic and most had been examined as outpatients.

Signs most strongly related to an infection included modifications in lack of scent and style, hair loss, chest ache, irregular liver enzymes, pores and skin rashes, fever and chills, fatigue and malaise. Situations most strongly related to an infection included myocarditis, acute respiratory misery and myositis. There was additionally a better affiliation with psychological well being remedy amongst youngsters who examined optimistic for PASC in contrast with those that examined adverse.


Journal reference:

Rao, S., et al. (2022 Medical options and burden of postacute sequelae of SARS-CoV-2 an infection in youngsters and adolescents. JAMA Pediatrics.

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