Maternal obesity during pregnancy causes metabolic perturbations in offspring’s liver and skeletal muscle
A latest examine in The FASEB Journal has recognized metabolic perturbations within the liver and skeletal muscle of younger nonhuman primates on regular diets whose moms had been overweight throughout being pregnant.
For the examine, tissue biopsies had been obtained from 19 post-pubertal offspring of moms who had been fed a Western food plan and had been overweight throughout being pregnant, and from 13 management animals born to non-obese moms fed a regular food plan. All offspring ate a wholesome chow food plan after weaning. Investigators recognized 58 metabolites considerably altered in liver and 46 in skeletal muscle of the offspring of moms with weight problems throughout being pregnant, with 8 metabolites shared between each tissues. A number of metabolic pathways had been recognized from these dysregulated metabolites. These variations in metabolites weren’t seen in blood samples taken from the animals.
This examine is thrilling for 2 causes: First it exhibits that publicity to an unhealthy setting in utero has long-term well being penalties, and totally different organs and tissues are affected in several methods. Second, our evaluation suggests you can’t simply analyze blood samples to know what is going on within the liver or muscle.”
Michael Olivier, PhD, Corresponding Creator, Wake Forest College College of Drugs
Ampong, I., et al. (2022) Maternal weight problems alters offspring liver and skeletal muscle metabolism in early post-puberty regardless of sustaining a standard post-weaning dietary way of life. The FASEB Journal. doi.org/10.1096/fj.202201473R.