Butyrate in human milk negatively associated with infant weight and BMI


Human milk (HM) incorporates butyrate, a short-chain fatty acid (SCFA). This four-carbon fatty acid is current in HM at a different focus of 0.1–0.75 mg/100 mL. Butyrate has many organic features, similar to anti-inflammatory properties, and prevents insulin resistance and weight problems. A latest research within the journal Nutrients offered proof on the origin of HM butyrate primarily based on HM microbiota composition. This research additionally elucidated the maternal and antenatal components linked with HM butyrate focus.

Research: Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth. Picture Credit score: evso / Shutterstock


Earlier research have revealed that intestine anaerobic micro organism synthesize butyrate through fermentation of non-digestible carbohydrates. Amongst many SCFAs (e.g., acetate and propionate), butyrate is a big power supply utilized by colonic epithelial cells. 

Though a lot analysis associated to intestinal butyrate is out there, not many research have elucidated the origins of HM butyrate. It has been hypothesized that maternal intestine microbiota synthesizes butyrate, which could attain HM by maternal circulation. So far, no proof has been documented that signifies native butyrate manufacturing by in situ HM microbiota. As well as, it’s crucial to grasp whether or not maternal and pregnancy-related components affect HM butyrate focus.

Infants are launched to this fatty acid by oral consumption of HM or strong meals. One other approach by which infants obtain butyrate is bacterial fermentation of dietary compounds, notably human milk oligosaccharides (HMOs), within the colon. Therefore, HM butyrate doesn’t signify the precise butyrate focus consumed by infants. The advantages of HM butyrate for infants have been indicated in lots of research. As an example, HM butyrate prevents pointless weight and adiposity acquire, which considerably decreases later weight problems danger. Subsequently, it is very important measure absolutely the butyrate consumption through HM to raised perceive the mechanistic hyperlinks with weight and adiposity beneficial properties.

In regards to the Research

This present longitudinal potential cohort is a part of the Cambridge Child Progress and Breastfeeding Research which goals to elucidate the components in HM that affect infants’ development price and establish parameters that improve the chance of weight problems in later life. The authors measured the whole HM consumed by a child utilizing a deuterium-labeled water method. The HM composition, i.e., its macronutrients, butyrate, HMOs, HM microbiota, and toddler’s intestine microbiome, was additionally evaluated.

On this research, mother-infant pairs have been recruited at beginning on the Rosie Maternity Hospital in England. Wholesome moms with wholesome physique mass index (BMI) earlier than being pregnant and who had the intention of breastfeeding as much as at the very least six weeks of the infants’ age have been included on this research.

Start weights have been obtained at completely different time factors, i.e., at beginning, 2 and 6 weeks, after which 3, 6, and 12 months. A Holtain Tanner/Whitehouse Skinfold Caliper was used to measure relative subcutaneous physique fats and skinfold thickness (SFT). HM samples have been collected to find out composition.

Research Findings

A complete of 71 wholesome singletons have been included on this longitudinal research to research how HM butyrate influences toddler development. Total, detrimental associations have been discovered between HM butyrate concentrations and measures of toddler weight and adiposity. This discovering was consistent with a earlier research that reported butyrate to stop extreme weight acquire and weight problems throughout childhood.

Since HM butyrate focus was discovered to be inversely correlated with HM consumption quantity, it was presumed that prime butyrate focus in HM might be the explanation for low HM consumption in some infants. The authors speculated that butyrate odor and/or style in HM and its means to control urge for food can probably lower toddler HM consumption. This may additionally trigger early attenuation from HM consumption, leading to early toddler weight acquire.

Notably, the present research reported a relative abundance of Oscillospira in HM, a standard butyrate producer. Nonetheless, different butyrate producers, similar to Faecalibacterium prausnitzii, Roseburia intestinalis, or Eubacterium rectale, weren’t detected. The authors didn’t anticipate the presence of butyrate-producing micro organism of the intestine microbial group, usually anaerobes, in HM. Subsequently, elevated bacterial metabolism might be attributed to the elevated HM butyrate ranges and to not modifications in bacterial group composition.

Curiously, a constructive correlation between butyrate concentrations and non-butyrate-producing bacterial taxa in HM (e.g., Acinetobacter sp.) was noticed. The abundance of Acinetobacter in HM microbiota was related to meals allergy in infants. As well as, butyrate exhibited an antimonial impact on sure strains of Acinetobacter; subsequently, the abundance of this species was not related to butyrate synthesis.


HM butyrate was discovered to be negatively related to infants’ development. Nonetheless, this affiliation was discovered to weaken with age, probably due to the child’s introduction to different types of diet. Notably, a weak relationship between HM butyrate and HM microbiota composition was noticed on this research.

Leave A Reply