Differences in gut bacteria can be early indicators for the development of peanut allergies


A brand new examine led by researchers on the Icahn Faculty of Medication at Mount Sinai has revealed key variations in intestine micro organism and their metabolic byproducts in infants which will predict the event of peanut allergy symptoms by mid-childhood. The findings, revealed on-line August 22 within the Journal of Allergy and Medical Immunology, may pave the way in which for brand new methods to forestall or deal with this more and more frequent meals allergy.

The multi-center longitudinal examine monitored infants recognized to be in danger for allergy symptoms however who hadn’t but developed a peanut allergy. By analyzing fecal samples from infancy and later in childhood, the researchers have been in a position to determine particular variations in intestine micro organism and the metabolites they produce between kids who did and didn’t develop a peanut allergy by round age 9.

Key findings of the examine embody:

  • Infants who ultimately developed peanut allergy symptoms had decrease intestine microbiome variety throughout their early years.
  • Particular courses of micro organism, together with Clostridium and Bifidobacterium, and sure metabolites like butyrate and isovalerate have been discovered in numerous patterns in kids who developed peanut allergy symptoms.
  • Metabolites related to peanut allergy growth have been linked to the “histidine metabolism pathway” – a course of within the physique that breaks down and makes use of the protein constructing block histidine.

Senior writer, Supinda Bunyavanich, MD, MPH, MPhil, the Mount Sinai Endowed Professor in Allergy and Methods Biology and Deputy Director of the Elliot and Roslyn Jaffe Meals Allergy Institute, highlighted the importance of the examine: “It is a main step ahead to grasp that particular patterns of intestine micro organism and their metabolic merchandise may be early indicators for the event of peanut allergy symptoms. This presents a novel perspective into potential preventive methods that would have a profound influence on how we tackle peanut allergy symptoms in kids.”

Nonetheless, Dr. Bunyavanich additionally cautioned in opposition to drawing untimely conclusions: “Whereas it is thrilling to assume our intestine micro organism would possibly affect our danger of creating allergy symptoms, it is essential to notice that altering a baby’s intestine micro organism is not but a direct resolution. We want additional analysis to actually harness these findings.”

The examine is likely one of the first of its form to longitudinally observe modifications in intestine micro organism and their byproducts from infancy to childhood, particularly in relation to peanut allergy growth. The insights gleaned may result in progressive approaches, similar to probiotics or dietary interventions, to handle and forestall peanut allergy symptoms in kids, enhancing numerous lives.

The researchers acknowledge that whereas their findings current sturdy associations between the intestine atmosphere and peanut allergy growth, it is not but confirmed that these bacterial modifications instantly trigger the allergy. Future research with expanded pattern sizes and scientific trials might be important to strengthen these hyperlinks.


Journal reference:

Chun, Y., et al. (2023) Longitudinal dynamics of the intestine microbiome and metabolome in peanut allergy growth. Journal of Allergy and Medical Immunology. doi.org/10.1016/j.jaci.2023.08.012.

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